Evaluation of Antibiotics used and Treatment Outcomes in Postoperative Appendectomy Patients

Background: Appendicitis is condition which describes and explain inflammation of appendix.^[1] Signs and symptoms of appendicitis are generally severe discomfort in lower right part of abdominal cavity, vomiting, nausea and loss of appetite while around 40% of people do not show these distinctive characteristics of appendicitis.^[2] For management of acute appendicitis appendectomy is required on urgent basis as appendectomy. The incidence of surgical wound infections or surgical sites infections are greatly reduced by administration of antibiotics prophylactically. Methodology: This cross sectional study was conducted for minor and major surgery patients of appendicitis at Sandman Provincial Hospital Quetta and Bolan Medical Complex Hospital Quetta. The study was carried out over period of 4 months between May 2018 and September 2018. Convenient sampling method was adopted for enrolling study patients A standardized data collection form was developed based on recommendations of Center for Disease Control (CDC) guiding principle for inhibition of SSI was used. Ethical approval was obtained from Ethical Committee of Faculty of Pharmacy and Health Sciences, University of Balochistan Quetta. Results: Results showed that majority of patients of appendicitis 133 (68.2%) were from age group 1 to 20 years. Majority of participants that had undergone surgery for appendicitis were male 114 (58.5%). Majority of respondents belonged to the urban area i.e 123. Outcomes on follow up showed majority of the patients had healed their wound which were using prescribed antibiotics for post-operative care. Only one patient reported the sepsis. Metronidazole was prescribed to most of the patient’s i.e 183, Ceftriaxone to 162, Gentamicin to 155, Moxifloxacin to 19 among other antibiotics. Conclusion: The current study demonstrated that antibiotics are rationally prescribed in tertiary care hospitals of Quetta, also prophylactic and post-operative prescribing of antibiotics yield the desired outcomes.